Thursday 1 August 2013

'FAP' AND COLON CANCER

In the 'FAP' Associated Model , spontaneous cases of 'Colon Cancer' begin with a Mutation in the APC gene. Which maps to the long arm of chromosome 5 .

 This mutation occurs in a normal epithelial cell in the living of the colon ,In spontaneous causes ,an APC Mutation causes epithelial cells to partially escape cell cycle control .These cells divide to form a small cluster called polyp .those who inherit a mutant APC allele have the mutation in all cells of their body .As a result , APC Hetero Zygotes from hundreds or thousand of polyps .



   In either case ,polyps are clones ,all of which carry an APC Mutation .The loss of corresponding allele on the homologous copy of Chromosome 5 is not necessary for polyp formation .The first step and the relative order of subsequent mutations .Subsequent Mutations in polyp cells causes Intermediate stages of tumor formation .Mutations in the ras onco gene on chromosome 12 ,cause polyp to grow larger and to devlop finger like outgrowths .This is the Intermediate adenoma stage .




  To progress further ,a polyp cell must acquire Mutations in the DCC (Detected Colon Cancer) gene on chromosome 18 .
Mutations in both DCC alleles results in late - stage adeno-mas .Finally ,Mutation of the p53 gene causes the transition to a cancerous call .As described earlier , Mutations in p53 are pivotal to cancers including LUNG ,BRAIN as well as Colon Cancer .
Metastasis occurs after the formation of Colon Cancer ,and it's involves an unknown number of Mutational steps .

3 comments:

  1. I want to share with you all on how Dr Itua saves my life with his powerful Herbal medicines, I was diagnosed of Oral/Ovarian Cancer which i suffered from for 5 years with no positive treatment until when My son came to me in the hospital when i was laying down on my dying bed waiting for god to call out my name to join him in heaven.
    My son was so excited that very day he came across Dr Itua on Blogspot, we decided to give him a try although we Americans are so scared to trust Africans but i really have no choice that time to choose life in between so we gave a try to Dr Itua Herbal medicines, god wiling he was a good man with a god gift. Dr Itua send us the herbal medicine it was three bottles. I take it for three weeks instructor and this herbal medicines heal me, cure my Oral/Ovarian Cancer completely I have been living for 9 months now with healthy life no more symptoms.
    I'm sponsoring Dr Itua in LA Advert on Cancer patent seminar which my son will be participating too and other patent Dr Itua has cured from all kind of human disease, also if you are sick from disease like,Epilepsy,Breast Cancer,Prostate Cancer,Throat cancer,Thyroid Cancer,​Uterine cancer,Fibroid,Angiopathy, Ataxia,Arthritis,Brain cancer,Hiv,. Vaginal cancer,Herpes,Colon-Rectal Cancer,Chronic Disease.Amyotrophic Lateral Scoliosis,Brain Tumor,Fibromyalgia,Fluoroquinolone Toxicity,​Multiple myeloma,Tach Diseases,Leukemia,Liver cancer,
    ​Esophageal cancer,​Gallbladder cancer,,Bladder cancer,Gestational trophoblastic disease,Head and neck cancer,​Hodgkin lymphoma
    ​Intestinal cancer,Kidney cancer,Hpv,Lung cancer,Adrenal cancer.Bile duct cancer,Bone cancer,Melanoma,Mesothelioma,​Neuroendocrine tumors
    Non-Hodgkin lymphoma,Cervical Cancer,​Oral cancer,Hepatitis,Skin cancer,Soft tissue sarcoma,Spinal cancer,Pancreatic Cancer, Stomach cancer
    ​Testicular cancer,
    Syndrome Fibrodysplasia Ossificans ProgresSclerosis,Alzheimer's disease,Chronic Diarrhea,Copd,Parkinson,Als,Adrenocortical carcinoma Infectious mononucleosis,​Vulvar cancer,Ovarian cancer,,​Sinus cancer, Here Is The Wonderful Healer Contact. Name_ Doctor Itua, Email Contact: drituaherbalcenter@gmail.com, Phone/WhatsApp: +2348149277967

    ReplyDelete
  2. Hello everyone, i'm Linda Harry from United State i was diagnosed with Parkinson Disease  for over 6 years which made me loose my job and my relationship with my Fiance after he discovered that i was having Parkinson, he departed from me, and i tried all my best to make him stays, but he neglected me until a friend of mine  from UK told me Great healer, who will restore my life back with his powerful healing herbal medicine. then he  sent me his email address to contact him- drimolaherbalmademedicine@gmail.com. and i quickly contacted him, and he said my condition can be solved, that he will treat the disease immediately only if i can accept trust on him and accept his terms and condition, i Agreed because i was so much in need of help by all means, so i did all he instructed me to do. And surprisingly after two weeks, He sent me a text, that i should hurry up to the hospital for a checkup, which i truly did, i confirm from my doctor that i am now ( PARKINSON NEGATIVE) my eyes filled with tears and joy, crying heavily because truly the disease deprived me of many things from my life, This is a Miracle, dr imoloa also uses his powerful herbal medicine to cure the following diseases:  lupus disease,  mouth ulcer,  mouth cancer, body pain, fever, hepatitis A.B.C.,   syphilis,  diarrhea,  HIV/AIDS,  Huntington's Disease,   back acne,  Chronic renal failure,   addison disease,  Chronic Pain,   Crohn's Disease,   Cystic Fibrosis,  Fibromyalgia,   Inflammatory Bowel Disease,  fungal nail disease, Lyme Disease, Celia disease, Lymphoma, Major Depression,  Malignant Melanoma,   Mania,  Melorheostosis,   Meniere's Disease,  Mucopolysaccharidosis , Multiple Sclerosis,  Muscular Dystrophy,  Rheumatoid Arthritis, Alzheimer's Disease, parkison disease, vaginal cancer, epilepsy,  Anxiety Disorders, Autoimmune Disease,   Back Pain,  Back Sprain,   Bipolar Disorder,  Brain Tumour,  Malignant,   Bruxism, Bulimia,  Cervical Disk Disease, cardiovascular disease, Neoplasms, chronic respiratory disease,  mental and behavioural disorder,     Cystic Fibrosis,   Hypertension, Diabetes, asthma,  Inflammatory autoimmune-mediated arthritis.  chronic kidney disease, inflammatory joint disease,  impotence,  feta alcohol spectrum,  Dysthymic Disorder,   Eczema, tuberculosis,  Chronic Fatigue Syndrome, constipation, inflammatory bowel disease, bone cancer, lung cancer. contact him on email- drimolaherbalmademedicine@gmail.com. and also on whatssap- +2347081986098

    ReplyDelete
  3. Most prostate cancers are adenocarcinomas, cancers that arise in glandular cells of the prostate’s epithelial tissue. Prostate cancers usually progress slowly and produce no symptoms in the initial stages. Eventually, the tumor may enlarge like mine use too, the prostate gland, pressing on the urethra and causing painful or frequent urination and blood in the urine. So I was so uncomfortable with this prostate cancer diseases then I decided to do online search on how to cure cancer because I well have read a lot about herbal medicine, I came across a lot of testimony how Dr Itua cure HIV/herpes then Cancer was listed below the comment.with courage I contacted Dr Itua and he sent me his herbal medicine through Courier service then I was asked to pick it up at my post office which i quickly did. I contacted Dr Itua that i have received my herbal medicine so he instructs me on how to drink it for three weeks and that is how Dr Itua Herbal Medicine cure my prostate Cancer, The treatment takes three weeks and I was cured completely. Dr Itua is a god sent and I thank him every day of my life. Contact him now On:Email:drituaherbalcenter@gmail.com/   Whatsapp:+2348149277967.
    He listed to that he can as well cure the following diseases below.... Cerebral Amides. Lung Cancer,Brain cancer,Esophageal cancer,Gallbladder cancer,Gestational trophoblastic disease,Head and neck cancer,Hodgkin lymphoma Intestinal cancer,Kidney cancer,Leukemia,Liver cancer,Melanoma,Mesothelioma,Multiple myeloma,Neuroendocrine tumors,Hodgkin lymphoma,Oral cancer,Ovarian cancer,Sinus cancer,Soft tissue sarcoma,Spinal cancer,Stomach cancer,Meniere's disease , Testicular cancer,Throat cancer,Thyroid Cancer,Uterine cancer,Vaginal cancer,Vulvar cancer. Alzheimer's disease,Autism,measles, tetanus, whooping cough, tuberculosis, polio and diphtheria Adrenocortical carcinoma. Alma, Uterine Cancer, Breast Cancer, Allergic diseases. Kidney cancer, Love Spell, Glaucoma., Cataracts,Macular degeneration,Cardiovascular disease,Lung disease.Enlarged prostate,Osteoporosis.Generalized dermatitis,Alzheimer's disease,Brain Tumor,Lupus,Endomertil Cancer, cerebrovascular diseases  
    Dementia.Colo rectal cancer, Lottery Spell, Bladder Cancer, Skin Cancer,Ovarian Cancer,Pancreatic Cancer, HIV /Aids,Brain Tumor, Herpes, Non-Hodgkin lymphoma, Inflammatory bowel disease, Copd, Diabetes, Hepatitis  

    ReplyDelete

Related Posts Plugin for WordPress, Blogger...

Code