Epidemiological Survey show that Individuals who devlop a form of Liver cancer known as Hepato-cellular carcinoma (HCC) are infected with the Hepatitis B Virus (HBV) .
The infection produces a wide range of responses ,from chronic ,Self - limiting infections with few Symptoms ,to active hepatitis and Cirrhosis , to total Liver disorders and Hepato-cellular carcinoma .
In the last few years ,efforts have centered on understanding the mechanism by which HBV replicates and it's role in causing Liver Cancer .
The possible outcomes following cellular infection with Hepatitis B virus (HBV) .Following the Integration of the Viral Chromosome into the Human genome .Oncogenes can be activated resulting in Tumor Formation .Integration of the HBV genome can also cause Chromosome Instability .
Including the production of trans-locations and deletions the trigger a malignant cyclin Agene ,triggering abnormal regulation of the cell cycle and cellular proliferation ,resulting cancer Formation .
In-fact ,for those carrying HBV ,the risk of Cancer increases by a factor of 100 .
It's Most prevalent in Asia , and tropical region of Africa .
The infection produces a wide range of responses ,from chronic ,Self - limiting infections with few Symptoms ,to active hepatitis and Cirrhosis , to total Liver disorders and Hepato-cellular carcinoma .
In the last few years ,efforts have centered on understanding the mechanism by which HBV replicates and it's role in causing Liver Cancer .
The possible outcomes following cellular infection with Hepatitis B virus (HBV) .Following the Integration of the Viral Chromosome into the Human genome .Oncogenes can be activated resulting in Tumor Formation .Integration of the HBV genome can also cause Chromosome Instability .Including the production of trans-locations and deletions the trigger a malignant cyclin Agene ,triggering abnormal regulation of the cell cycle and cellular proliferation ,resulting cancer Formation .
